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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Fig. 2

Phosphorylated MLKL, a marker of necroptosis is reduced in RIP knockout animals. a. Exemplary staining of pMLKL and NeuN (upper panel) and a pMLKL positive neuron at higher magnification (lower panel) in the rim of a traumatic contusion in a wild type mouse. b. pMLKL is significantly reduced in a RIPK3 deficient mouse. c and d p-MLKL signal intensity was significantly increased after TBI in wild type animals (white bars) compared to sham animals indicating significant presence of necroptosis three months after TBI; this increase was significantly blunted in RIPK1 (c) as well as in RIPK3 d mice where there was no difference between TBI and sham animals. Data are presented as mean ± SD; n = 9–10 for RIPK1, n = 8–9 for RIPK3. Two-way RM ANOVA with Tukey’s multiple comparisons test was used. ***p < 0.001, n.s. indicates no significant statistical difference between groups

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Acta Neuropathologica Communications

ISSN: 2051-5960

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