Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Single-cell multimodal analysis in a case with reduced penetrance of Progranulin-Frontotemporal Dementia

Fig. 2

Overview of the experimental approach and CITE-Seq datasets. A Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-Seq) multi-modal analysis of nuclei isolated from frozen Brodmann area 10 (BA10) which includes NC.38, AMC.26 and reduced penetrance (RedPenMC, refer Additional file 2: Table S1 & S2a). NC.38 frozen brain was obtained from Mount Sinai Brain bank part of NIH Brain and Tissue Repository (NIH NeuroBioBank, USA). AMC.26 and RedPenMC frozen brain were obtained from Brain Bank at Karolinska Institutet, Sweden. B UMAP of integrated snRNA-Seq 18,266 profiles from AMC.26, NC.38 and RedPenMC annotated according to the expression of known markers. C Known markers for pan-neuronal, excitatory neurons, glial and endothelial cells (OPCs: Oligodendrocyte progenitor cells). D Representative protein profiles for different cell types after normalization of the unique molecular identifier (UMI) counts, (ADT Antibody derived tags)

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us