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Table 1 Patient data

From: Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

  

Cognitive status

 
 

Overall

Normal

Impaired*

p

Demographics

Average age at testing (range)

83.2 (52.9–105.1)

81.0 (52.9–102.4)

88.3 (69.8–105.1)

 < 0.0001

Total (Male / Female)

174 (82 / 92)

124 (63 / 61)

50 (19 / 31)

0.126***

Age at last visit (%)

 < 60

7 (4.0)

7 (5.6)

0 (0.0)

 

60–69

15 (8.6)

14 (11.3)

1 (1.7)

 

70–79

33 (19.0)

30 (24.2)

3 (5.2)

 

80–89

76 (43.7)

45 (36.3)

31 (53.4)

 

90 + 

51 (29.3)

28 (22.6)

23 (39.7)

 

Education, at least some college (%)

32 (18.4)

15 (78.9)

17 (77.3)

0.89

History of psychiatric illness (%)

45 (25.9)

29 (31.9)

17 (45.9)

0.13

Neuropathological data

Argyrophilic grains

32 (18.4)

12 (9.7)

10 (20.0)

0.06

Lewy body pathology (incidental)

16 (9.2)

11 (8.9)

5 (10.0)

0.82

Cerebrovascular disease**

27 (15.5)

6 (4.8)

21 (42.0)

 < 0.0001

Infarcts (vascular brain injury)

37 (21.3)

24 (19.4)

13 (26.0)

0.33

Hippocampus ARTAG positive (%)

43 (24.7)

25 (21.6)

18 (38.3)

0.03

Genetic data

Presence of ≥ 1 APOE ε4 allele

22 (12.6)

16 (12.9)

6 (11.3)

0.77

Presence of ≥ 1 APOE ε2 allele

46 (26.4)

27 (21.8)

19 (35.8)

0.06

Presence of ≥ 1 MAPT H2

59 (33.9)

42 (36.2)

17 (36.2)

1

  1. * Mild cognitive impairment or dementia, ** excluding cerebral amyloid angiopathy, ***Male sex, significant values in bold (Chi squared test)