Fig. 9

Normalization of mTORC1 and SREBP-mediated lipogenesis pathways in the cortex of APP/PS1/FTnKO mice. A Heatmap of RNA expression z-scores computed for selected genes in the cholesterol homeostasis and mTORC1 signaling pathways across the three genotypes. The color gradient of the bars on the right reflect the log2(fold change) of the genes, and the genes that are significantly downregulated or upregulated (FDR < 0.05) are indicated by an asterisk (*). B Table of top downregulated mSigDB Hallmark pathways and the corresponding differentially expressed genes (DEGs) in APP/PS1/FTnKO mice compared with APP/PS1 mice. C Table of key transcriptional regulators identified through upstream regulator analysis using Ingenuity Pathway Analysis (IPA) software. Based on the log2(fold change) of downstream target genes, the activity of the upstream regulator is predicted using activation z-score. D Network of Raptor, a regulatory associated protein of mTOR, and its targeted genes. Edges (lines between nodes) represent direct (solid lines) and indirect (dashed lines) interactions as supported by information in the Ingenuity knowledge base