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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Fig. 8

Transcriptomic analysis of frontal cortex from APP/PS1/FTnKO, APP/PS1, and WT mice. A Volcano plot for cortical transcriptome analysis of APP/PS1/FTnKO versus APP/PS1 mice at 9–10 months (n = 6/genotype). Red and blue points represent upregulated and downregulated genes below the significance threshold (FDR < 0.05), respectively. B Top enriched pathways categorized by mSigDB Hallmark gene set database in differentially downregulated genes in APP/PS1/FTnKO mice compared with APP/PS1 controls. C Volcano plot for cortical transcriptome of WT (n = 5) versus APP/PS1 mice (n = 6) at 9–10 months. D Top enriched mSigDB Hallmark pathways of significantly upregulated genes (FDR < 0.05) in the cortex of APP/PS1 mice compared with WT controls

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Acta Neuropathologica Communications

ISSN: 2051-5960

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