Fig. 6

Reduced Aβ deposition in APP/PS1/FTnKO mice. A Representative brain sections from APP/PS1 and APP/PS1/FTnKO mice immunostained with anti-Aβ antibody (6E10). Scale bar, 500 μm. B, C Cortex and Hippocampal Aβ loads determined by immunohistochemical and morphometric analyses with the Aβ-positive area in the APP/PS1 control group set as 100%. D, E Quantification of small (< 20 µm), medium (20–50 µm), and large (> 50 µm) amyloid plaques in the cortex and hippocampus. F Representative brain sections from APP/PS1 and APP/PS1/FTnKO mice immunostained for activated microglia using anti-IBA1 antibody. Scale bar, 500 μm. (G, H) Microglial activation in the cortex and hippocampus determined by morphometric analyses with the IBA1-positive area in the APP/PS1 control group set as 100%. n = 8 mice/genotype; Student’s t-test, 2-tailed; *p < 0.05; ***p < 0.001