| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
---|---|---|---|---|---|
Macroscopic analysis | |||||
 Brain weight | 1117 gr | 1410 gr | 1260 gr | 1010 gr | 975 gr |
 Atrophy | FT-Right | FT | FT-Right | FT | T |
 Substantia nigra | Normally pigmented | Normally pigmented | Slightly pale | Pale | Slightly pale |
 Locus coeruleus | Visible | Visible | Right < Left | Not visible | Visible |
 Atherosclerosis | No | Moderate | Severe | Mild | No |
Microscopic analysis | |||||
 Plaque and tangles | Negative | Negative | Thal 3 | Negative | Negative |
 Congo red | Negative | Negative | Negative | Negative | Negative |
 Alpha synuclein | Negative | Negative | Negative | Braak 3 | Negative |
 Tau | Negative | Negative | Positive | Negative | Negative |
 Pick Bodies | No | No | No | No | No |
 TDP-43 | Positive | Positive | Negative | Negative | Positive |
 FUS | Negative | Negative | Negative | Positive | Negative |
 Accumulation | All layers | Predominantly layer 2 | 3R + 4R | FUS | Several long threads |
 Frontal |  +  +  |  +  +  |  +  +  +  |  +  +  +  |  +  |
 Temporal |  +  +  +  |  +  +  +  |  +  +  + * |  +  +  +  |  +  +  +  |
 Motor cortex |  +  +  +  | – | – | n/a | – |
 Corticospinal tract |  +  +  +  | – | – | – | – |
 Parietal | – | – |  +  +  | n/a |  +  |
 Occipital | – | – |  +  | – | – |
 Hippocampus |  +  +  +  |  +  +  +  |  +  +  +  |  +  +  +  |  +  +  +  |
 Amygdala |  +  +  +  |  +  +  +  |  +  +  +  |  +  +  +  |  +  +  +  |
 Caudate, putamen | – |  +  +  |  +  +  +  |  +  +  +  |  +  +  |
 Thalamus | – |  +  +  |  +  +  |  +  +  +  |  +  +  |
 Brain stem | – | – |  +  +  +  |  +  +  +  | – |
 Cerebellum | – | – | – | – | – |
 Cervical cord |  +  +  +  | – | – | – | – |
Diagnosis | FTLD-TDP type B + MND | FTLD-TDP type E | FTLD-MAPT | FTLD-FUS | FTLD-TDP type C |