| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 |
---|---|---|---|---|---|
Age | 58 | 68 | 59 | 59 | 63 |
Sex | Male | Male | Male | Male | Female |
Handedness | Right | Right | Right | Right | Right |
Symptoms | |||||
 Prosopagnosia | √ |  | √ |  | √ |
 Memory deficit | √ | √ | √ | √ | √ |
 Disinhibition | √ | √ | √ | √ |  |
 Apathy-inertia | √ | √ | √ | √ | √ |
 Alexithymia |  |  | √ | √ | √ |
 Bizarre preoccupations | √ | √ | √ | √ | √ |
 Lack of logical reasoning | √ | √ | √ | √ | √ |
 Pathological dwelling on one activity | √ | √ | √ | √ | √ |
 Change of personal taste |  | √ | √ |  |  |
 Nicotine/alcohol abuse |  | √ |  |  |  |
 Hyperalgesia |  |  | √ | √ |  |
 Over sleeping during the day | √ |  |  | √ |  |
 Word finding difficulties | √ | √ |  | √ | √ |
 Naming difficulties | √ |  |  |  | √ |
 Single word comprehension deficit |  |  |  |  | √ |
 Depression | √ | √ | √ | √ | √ |
 Slowness | √ | √ | √ | √ |  |
 Motor restless |  |  |  | √ |  |
 Hyper-orality |  |  |  |  |  |
Diagnosis prior to autopsy | FTD + MND | FTD | FTD + atypical parkinsonism | FTD | FTD |
Family History | Father had psychiatric symptoms, sister had paranoid disorder | Two brothers and mother had dementia at the age of 70Â s with behavioural problems | Mother had psychiatric symptoms and attempt a suicide, uncle (maternal) had dementia at the age of 85 | Father and brother had depression, son had ADHD | Mother attempt a suicide |
MRI anterior temporal R/L | 2/0 | 3/2 | 2/0 | 3/1 | 4/3 |
MRI mesial temporal R/L | 3/0 | 4/3 | 2/1 | 4/0 | 3/2 |
MRI frontal R/L | 1/0 | 1/1 | 1/0 | 1/1 | 1/0 |
SPECT/PET | Right temporal hypo-perfusion | N.A | Right temporal hypo-perfusion | N.A | N.A |
Genetic analysis | N.A | N.A | MAPT (+) Ser352Leu | N.A | MAPT (negative) PRGN (negative) C9orf72 (negative) |
CDR | 0.5 | 0.5 | 0.5 | 0.5 | 1 |
MMSE | 27/30 | 25/30 | 23/30 | 22/30 | 25/30 |
FAB | N.A | N.A | 14/18 | 18/18 | 14/18 |
VAT-A | N.A | 6/12 | 4/12 | 4/12 | 7/12 |
RAVLT delayed recall | N.A | 0/15 | N.A | 12/15 | N.A |
VAT naming | N.A | N.A | 10/12 | 12/12 | 6/12 |
Digit span forward | N.A | N.A | 12/16 | 13/16 | 8/16 |
Digit span backward | N.A | N.A | 8/16 | 7/16 | 8/16 |
TMT A | N.A | N.A | 57’’ (A) | 69’’ (A) | 49’’ (A) |
TMT B | N.A | N.A | 169’’ (LA) | 166’’ (LA) | 102’’ (A) |
VOSP-Dot Counting | N.A | N.A | 10/10 | 8/10 | 9/10 |