Table 1 Reclassification of the reported molecular neuropathologies
| Â | Publications | N | Reported molecular neuropathology | Adapted diagnosis |
|---|---|---|---|---|
1 | [52] | 1 | FTLD-TDP type C + CTD | FTLD-TDP type C + CTD |
2 | [69] | 1 | FTLD-tau-PSP + TDP type A | FTLD-tau-PSP + TDP type A |
3 | [54] | 9 | FTLD-tau-PiD (n = 1) FTLD-TDP type C (n = 8) | FTLD-tau-PiD (n = 1) FTLD-TDP type C (n = 8) |
4 | [61] | 1 | FTLD-TDP type C + tau-PSP | FTLD-TDP type C + tau-PSP |
5 | [64] | 1 | FTLD-TDP type A | FTLD-TDP type A |
6 | [63] | 1 | FTLD-TDP type A | FTLD-TDP type A |
7 | [70] | 1 | FTLD-tau-PiD | FTLD-tau-PiD |
8 | [67] | 1 | TDP-43 pathology in all cortical layers. NCI, with crescentic, round, skein-like and granular types. Short threads accompanied the NCI. Due to the admixture of neuronal cytoplasmic inclusion subtypes seen in FTLD-TDP type A and type B, presence of type A threads, but involvement of all cortical layers (type B), the pattern of TDP-43 inclusions is unclassifiable. Skein-like inclusions in lower motor neurons, producing the neuropathological diagnosis of motor neuron disease. Thal amyloid plaque stage 4, Braak 1. 4R-only atypical tauopathy | FTLD-TDP type A-B + AD + 4R tau |
9 | [55] | 1 | FTLD-tau-GGT | FTLD-tau-GGT |
10 | [38] | 7 | FTLD-TDP type C (n = 1) FTLD-TDP type C + CTD (n = 6) | FTLD-TDP type C (n = 1) FTLD-TDP type C + CTD (n = 6) |
11 | [56] | 2 | FTLD-TDP Mackenzie type 3 + MND (n = 1) TDP Mackenzie type 3 + MND + AD (n = 1) | FTLD TDP type B + MND* FTLD TDP type B + MND* + AD |
12 | [66] | 1 | FTLD-FUS | FTLD-FUS |
13 | [68] | 1 | FTLD-TDP Mackenzie type 3 + MND | FTLD-TDP type B + MND* |
14 | [60] | 1 | FTLD-TDP-43 pathology with NII | FTLD-TDP type A-B |
15 | [62] | 1 | FTLD-TDP Cairns type 2 + MND | FTLD-TDP type B + MND* |
16 | [65] | 1 | Immunohistochemistry using antibodies to ubiquitin showed NCIs, some of these inclusions were also immunoreactive for phosphorylated TDP-43 antibodies. We identified no DN, but a few NCI, which were positive for both ubiquitin and phosphorylated TDP-43 | FTLD-TDP type A-B + MND* |
17 | [4] | 1 | Mixed Alzheimer and cortical Lewy body disease (n = 1) | AD + DLB (n = 1) |
18 | [38] | 8 | FTLD-tau-PiD (n = 1) FTLD-tau-MAPT (n = 7) | FTLD-tau-PiD (n = 1) FTLD-tau-MAPT (n = 7) |
19 | [59] | 1 | TDP-43 pathology with NII | FTLD-TDP type A-B |
20 | [71] | 1 | Tau-negative, TDP-43-positive neuronal cytoplasmic inclusions and dystrophic neurites were found. Numerous NFTs and senile plaques with amyloid angiopathy indicated advanced Alzheimer disease | FTLD-TDP type A-B + AD |
21 | [58] | 1 | TDP43 pathology with NII + MND | FTLD-TDP type A-B + MND* |