Fig. 3

Adapted from Ulugut Erkoyun et al., 2020, Brain, CC BY-NC 4.0. The most common pathological accumulations in rtvFTD were FTLD-TDP type C, FTLD-tau and FTLD TDP type A or B. Since the pathology starts in the right temporal area, initial clinical features were right temporal lobe related symptoms. However, the progression pattern was heterogeneous in rtvFTD. While FTLD-TDP type C mostly spread to the contralateral temporal lobe and the clinical features were related with semantic impairment, FTLD-tau tended to spread to frontal areas, and patients developed more behavioural problems. FTLD-TDP type A/B had a strong relationship with pyramidal impairment. However, in rtvFTD, corticospinal tract impairment was common in FTLD-TDP type C pathology as well and atypical Parkinsonism might be expected in FTLD-tau cases. *: number of cases that have macroscopic atrophy pattern data