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Table 2 Partial Spearman correlations of semiquantitative MTL scores of neurodegenerative pathologies with MTL subregional thickness measures, including all pathologies in the same model

From: Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions

 

ERC

BA35

BA36

PHC

SUB

CA1

SRLM

Sample size

55

53

53

56

58

58

57

Amyloid-β

0.10

0.11

 − 0.02

 − 0.18

0.05

0.05

0.16

Tau

 − 0.26a

 − 0.31*

0.08

0.06

 − 0.13

 − 0.16

 − 0.33*

TDP-43

 − 0.44**

 − 0.46**

 − 0.35*

 − 0.45***

 − 0.27a

 − 0.39**

 − 0.46***

α-synuclein

0.01

 − 0.01

0.02

0.12

0.16

0.17

 − 0.12

  1. All models are corrected for age, sex and hemisphere
  2. ap < 0.10; *p < 0.05; **p < 0.01; ***p < 0.001. Significant results are bolded. TDP TAR DNA-binding protein, ERC entorhinal cortex, BA Brodmann area, PHC parahippocampal cortex, SUB subiculum, CA cornu ammonis, SRLM stratum radiatum lacunosum moleculare