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Table 1 Participant demographics

From: Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions

  Full dataset A-subset
Number of specimens 58 35
Sex (% male) 60.3 57.1
Age (years) Median (range) 75.0 (44–97) years 73.0 (44–93) years
Mean ± SD 74.7 ± 11.3 years 72.0 ± 10.7 years
MTL Tau score
Mean ± SD (range) 1.64 ± 0.93 (0–3) 1.34 ± 0.96 (0–3)
% score > 0 (N) 96.6% (56) 94.3% (33)
MTL TDP-43 score
Mean ± SD (range) 0.47 ± 0.91 (0–3) 0.52 ± 0.99 (0–3)
% score > 0 (N) 27.6% (16) 25.7% (9)
MTL amyloid-β scores
Mean ± SD (range) 0.92 ± 0.99 (0–3) 0.31 ± 0.59 (0–3)
% score > 0 (N) 63.8% (37) 40.0% (14)
MTL α-synuclein score
Mean ± SD (range) 0.21 ± 0.54 (0–2.33) 0.08 ± 0.30 (0–1.67)
% score > 0 (N) 17.2% (10) 8.6% (3)
Primary neuropathological diagnosis
None/limited pathologya 20.7% (8) 31.4% (7)
Intermediate-high ADNC 25.9% (15) 0% (0)
CBD 5.2% (3) 8.6% (3)
FTLD-TDP 13.8% (8) 20.0% (7)
LBD 8.6% (5) 2.9% (1)
Otherb 13.8% (7) 17.1% (6)
PART 8.6% (5) 14.3% (5)
Pick’s disease 5.2% (3) 8.6% (3)
PSP 6.9% (4) 8.6% (3)
Two or more neuropathological diagnoses 70.7% (41) 65.7% (23)
A score
0 25.9% (15) 42.9% (15)
1 34.5% (20) 57.1% (20)
2 8.6% (5) 0.0% (0)
3 31.0% (18) 0.0% (0)
B score
0 22.4% (13) 37.1% (13)
1 29.0% (18) 42.9% (15)
2 20.0% (11) 14.3% (5)
3 21.0% (13) 0.0% (0)
Missing 11.3% (3)b 5.7% (2)b
C score
0 55.% (32) 82.9 (29)
1 17.2% (10) 17.1% (6)
2 3.4% (2) 0.0% (0)
3 24.1% (14) 0.0% (0)
  1. The MTL pathology scores shown in the table are the averages of the semi-quantitative ratings in the entorhinal cortex, cornu ammonis 1 and dentate gyrus from the hemisphere contralateral to the MRI scan
  2. MTL medial temporal lobe, TDP TAR DNA-binding protein, ADNC Alzheimer’s disease neuropathological change, CBD corticobasal degeneration, FTLD frontotemporal lobar degeneration, LBD Lewy body disease, PART primary age-related tauopathy, PSP progressive supranuclear palsy. aAlso includes patients with low ADNC. bB score was difficult to establish for some cases because they had primary tauopathies. b”Other” includes the following primary neuropathological diagnoses: Amyotrophic Lateral Sclerosis (n = 1); Argyrophylic Grain Disease (n = 2); cerebrovascular disease (n = 1); multiple system atrophy (n = 1); other (n = 1); tauopathy unclassifiable (n = 1)