Table 1 Participant demographics
From: Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions
Full dataset | A-subset | |
|---|---|---|
Number of specimens | 58 | 35 |
Sex (% male) | 60.3 | 57.1 |
Age (years) Median (range) | 75.0 (44–97) years | 73.0 (44–93) years |
Mean ± SD | 74.7 ± 11.3 years | 72.0 ± 10.7 years |
MTL Tau score | ||
Mean ± SD (range) | 1.64 ± 0.93 (0–3) | 1.34 ± 0.96 (0–3) |
% score > 0 (N) | 96.6% (56) | 94.3% (33) |
MTL TDP-43 score | ||
Mean ± SD (range) | 0.47 ± 0.91 (0–3) | 0.52 ± 0.99 (0–3) |
% score > 0 (N) | 27.6% (16) | 25.7% (9) |
MTL amyloid-β scores | ||
Mean ± SD (range) | 0.92 ± 0.99 (0–3) | 0.31 ± 0.59 (0–3) |
% score > 0 (N) | 63.8% (37) | 40.0% (14) |
MTL α-synuclein score | ||
Mean ± SD (range) | 0.21 ± 0.54 (0–2.33) | 0.08 ± 0.30 (0–1.67) |
% score > 0 (N) | 17.2% (10) | 8.6% (3) |
Primary neuropathological diagnosis | ||
None/limited pathologya | 20.7% (8) | 31.4% (7) |
Intermediate-high ADNC | 25.9% (15) | 0% (0) |
CBD | 5.2% (3) | 8.6% (3) |
FTLD-TDP | 13.8% (8) | 20.0% (7) |
LBD | 8.6% (5) | 2.9% (1) |
Otherb | 13.8% (7) | 17.1% (6) |
PART | 8.6% (5) | 14.3% (5) |
Pick’s disease | 5.2% (3) | 8.6% (3) |
PSP | 6.9% (4) | 8.6% (3) |
Two or more neuropathological diagnoses | 70.7% (41) | 65.7% (23) |
A score | ||
0 | 25.9% (15) | 42.9% (15) |
1 | 34.5% (20) | 57.1% (20) |
2 | 8.6% (5) | 0.0% (0) |
3 | 31.0% (18) | 0.0% (0) |
B score | ||
0 | 22.4% (13) | 37.1% (13) |
1 | 29.0% (18) | 42.9% (15) |
2 | 20.0% (11) | 14.3% (5) |
3 | 21.0% (13) | 0.0% (0) |
Missing | 11.3% (3)b | 5.7% (2)b |
C score | ||
0 | 55.% (32) | 82.9 (29) |
1 | 17.2% (10) | 17.1% (6) |
2 | 3.4% (2) | 0.0% (0) |
3 | 24.1% (14) | 0.0% (0) |