Fig. 5From: Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mappingClustering of samples 1–9 based on their top 10,000 most differently methylated probes. A Unsupervised hierarchical clustering revealed 3 distinct clusters: the original tumor resection in the right temporal lobe (C1: sample 1), tumor in the ipsilateral cerebral hemisphere and brainstem (C2: samples 2, 3, 4, and 9), and tumor in the corpus callosum and contralateral cerebral hemisphere (C3: samples 5–8). B Phylogenetic relationship of each sample. C Spatial location of each tumor sample on standard MRI overlays. D Top-50 hyper- and hypo-methylated genes determined by pairwise comparison between clusters. Comparisons (C1 vs. C2) and (C1 vs. C3) share most of the hyper- and hypomethylated genes, whereas the comparison (C2 vs. C3) yields a separate set of differentially methylated genesBack to article page