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Table 1 Chronic traumatic encephalopathy (CTE) related pathology as

From: Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature

  1 week 4 weeks 24 weeks
Neuropathology considered Pathognomonic for CTE
 Perivascular p-Tau accumulation    
  P1: p-Tau immunoreactive neurons x x
  P2: p-Tau immunoreactive astrocytes x x
Neuropathological features Supportive of CTE
 P-Tau related pathologies
  S1: Cortical p-Tau (preferentially in superficial layers) x x
  S2: Hippocampal p-Tau
  S3: p-Tau present in subcortical nuclei    
   Mamillary bodies x x
   Amygdala
   Thalamus
  S4: Astroglial p-Tau in subpial and periventricular regions    
 p-Tau immunoreactive astrocytes in the subpial regions x x
 p-Tau immunoreactive astrocytes in the periventricular regions
Non-p-Tau related histological pathologies
  S5: TDP-43 immunoreactive neuronal cytoplasmic inclusions    
   Cortex x x
   Hippocampus x
   Amygdala
Select nonspecific neuropathological features Associated with CTE*
 A1: β-amyloid precursor protein depositions
 A2: α-synuclein depositions
 A3: Hemosiderin laden macrophages x x x
 A4: Reactive microglia x x
 A5: Astrogliosis x x x
 A6: Neuronal loss x x
 A7: Axonal loss x x
 A8: Blood brain barrier disruption X x not done
  1. *These selected histopathological features have been commonly reported to accompany CTE pathology but are not used to in the consensus criteria to define CTE. P, S, and A refer to pathognomonic, supportive, and associated pathology. “x “ and “–” denote histopathological feature present and absent in our model, respectively