Table 1 Chronic traumatic encephalopathy (CTE) related pathology as

Neuropathology considered Pathognomonic for CTE

 Perivascular p-Tau accumulation

  P1: p-Tau immunoreactive neurons

–

x

x

  P2: p-Tau immunoreactive astrocytes

–

x

x

Neuropathological features Supportive of CTE

 P-Tau related pathologies

  S1: Cortical p-Tau (preferentially in superficial layers)

–

x

x

  S2: Hippocampal p-Tau

–

–

–

  S3: p-Tau present in subcortical nuclei

   Mamillary bodies

–

x

x

   Amygdala

–

–

–

   Thalamus

–

–

–

  S4: Astroglial p-Tau in subpial and periventricular regions

 p-Tau immunoreactive astrocytes in the subpial regions

–

x

x

 p-Tau immunoreactive astrocytes in the periventricular regions

–

–

–

Non-p-Tau related histological pathologies

  S5: TDP-43 immunoreactive neuronal cytoplasmic inclusions

   Cortex

–

x

x

   Hippocampus

–

–

x

   Amygdala

–

–

–

Select nonspecific neuropathological features Associated with CTE*

 A1: β-amyloid precursor protein depositions

–

–

–

 A2: α-synuclein depositions

–

–

–

 A3: Hemosiderin laden macrophages

x

x

x

 A4: Reactive microglia

–

x

x

 A5: Astrogliosis

x

x

x

 A6: Neuronal loss

–

x

x

 A7: Axonal loss

–

x

x

 A8: Blood brain barrier disruption

X

x

not done