Fig. 3

Patterns and evolution of TDP43 (a–h) and pTDP43 (j–q) pathology in the cerebral cortex after repetitive closed head traumatic brain injury (rTBI) in the mouse. (f) Increased linear pattern of TDP-43 reactivity suggesting neuritic distribution at 1 week after rTBI. Nuclear loss (red arrowheads) and cytoplasmatic localization (white arrowheads) of TDP-43 (g-h) and pTDP-43 (p-q) at 4 and 24 weeks. Aggregation of cytoplasmatic localized TDP-43 (g-h) and pTDP-43 (q). (r) Apparent reduction in signal intensity of pTDP-43 in the cortex next to the impact center (§). Scale bars correspond to 240 µm for low power and 20 µm for high power magnified images. In each group, bars correspond to one cortical field of view (FOV) arranged from left, contralateral (contra), to right, ipsilateral (ipsi). Data are shown as mean (+ SD). n = 8 for sham, 1 week, and 4 week post rTBI and n = 4 for 24 week post rTBI. Analyses were done at Bregma − 1.67 mm (corresponding to s2 in Fig. 1) *P < 0.05. All analyses were done using one-way ANOVA on Ranks with post-hoc Dunn's