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Table 3 Case IHC data summary

From: Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

Case # Dx pSRRM2 MSUT2 AT180
10 AD Cytoplasmic Depleted +++
6 AD Cytoplasmic Depleted +++
8 AD Cytoplasmic Depleted +++
9 AD Cytoplasmic Depleted +++
16 AD Cytoplasmic Positive +++
5 AD Cytoplasmic Depleted +++
1 AD Cytoplasmic Depleted +++
2 AD Cytoplasmic Depleted +++
3 AD Cytoplasmic Depleted +++
7 AD Cytoplasmic Depleted ++
13 AD Cytoplasmic Positive ++
11 AD Cytoplasmic Depleted ++
4 AD Cytoplasmic Depleted ++
12 AD Cytoplasmic Positive ++
18 AD Mixed Depleted +++
17 AD Mixed Depleted +++
20 AD Mixed Positive ++
19 AD Mixed Depleted +
28 AD Nuclear Positive ++
23 AD Nuclear Positive ++
29 AD Nuclear Positive +
24 AD Nuclear Positive +
22 AD Nuclear Positive +
21 AD Nuclear Positive +
26 AD Nuclear Positive +
27 AD Nuclear Positive +
  1. +, mild; ++, moderate; +++, robust AT180 p-tau accumulation