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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

Fig. 3

pSRRM2 co-localizes with pathological tau in AD. a pSRRM2 (Red) is localized to the nucleus and pTau (pS422-Green) is cytoplasmic in cognitively normal elderly controls; visible overlapping signal is visualized as yellow (Pearson Coefficient of Colocalization = 0.017), (Panel image scale bar = 100um; inset scale bar = 25um). b pSRRM2 (Red) relocalizes to the cytoplasm and colocalizes with pTau (Green), as visualized in yellow in AD patients (Pearson Coefficient of Colocalization = 0.99). (Panel image scale bar = 100um; inset scale bar = 10um). c Proximity Ligation Assay imaging between pSRRM2 and pTau. Top: Panel image and inset imaging of PLA colocalization in a cognitively normal elderly control donor shows minimal cytoplasmic colocalization (Panel image scale bar = 100um; inset scale bar = 10um). Bottom: Panel image and inset imaging of PLA colocalization in an AD donor show significant colocalization in the cytoplasm (Panel image scale bar = 100um; inset scale bar = 10um)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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