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Table 2 Cytokines and chemokines detected in brain homogenates. Statistical analysis between WT and APP KI per age group

From: Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

Cortex Median (pg/ml) Median (pg/ml) Median (pg/ml) Median (pg/ml) LLOD LLOQ
2mo 4mo 8mo 18mo pg/ml pg/ml
P value WT APP KI   P value WT APP KI   P value WT APP KI   P value WT WT APP KI
IL-5 0.009 0.368 0.553 0.18 1.135 0.64 0.999 0.301 0.301   0.002 1.075 1.422 0.06 0.302
IL-4 0.03 0.338 0.461 0.589 0.357 0.334 0.143 0.264 0.304 0.002 0.336 0.463 0.11 0.818
IL-10 N/A NA NA   0 .818 2.034 2.098 NA NA NA   0.065 1.849 2.23 0.94 7.26
IL-27p28/1L-30 0.818 16.45 15.83 0.041 6.471 4.711 0.589 11.14 9.958 0.041 19.26 25.98 1.39 5.91
TNF-α 0.029 0.286 0.383 0.394 0.833 0.685 0.009 0.183 0.46 0.004 0.847 2.041 0.13 980
KC-GRO 0.002 3.092 5.03 0.002 30.47 11.66 0.026 4.811 7.914 0.002 13.57 26.45 0.24 3.29
IL-1β 0.065 0.434 0.533 0.24 0.587 0.695 0.065 0.712 1.865 0.002 0.816 5.292 0.11 0.72
IL-6 0.026 11.85 17.52 0.041 33.73 18.88 0.699 7.453 7.908 0.002 29.61 39.1 0.61 7.61
IL-2 0.052 0.502 0.910 0.132 1.399 0.825 0.143 0.491 0.588 0.002 1.107 1.559 0.22 1.03
IL-12p70 0.004 54.45 78.36 0.31 125.1 72.88 0.589 24.36 31.69 0.026 106.5 129.1 9.95 179
IFN-y 0.009 0.226 0.31 0.121 0.086 0.045 0.258 0.212 0.191 0.002 0.07 0.12 0.04 0.39
MIP-2 0.18 1.054 1.313 0.004 2.973 1.4 0.002 1.243 2.401 0.002 2.395 5.52 0.053 0.58
IP-10 0.093 6.532 5.619 0.485 11.98 13.33 0.002 6.189 33.32 0.002 9.174 109.8 0.328 2.15
MIP-1α 0.18 8.51 9.634 0.002 6.763 61.42 0.002 5.454 167.1 0.002 11.03 353.3 0.081 0.38
IL-15 0.818 176.4 174.2 0.002 72.01 49.71 0.818 176.5 165.6 0.041 233.5 296.1 16 43.2
IL-17A/F 0.513 6.004 6.231 0.004 6.024 3.43 0.485 6.001 4.217 0.041 9.669 11.7 0.231 1.39
MCP-1 0.132 31.495 33.37 0.286 13.32 14.95 0.132 27.6 21.52 0.004 37.3 51.76 0.672 4.42
IL-9 0.31 10.743 12.11 0.009 16.28 11.99 0.222 11.52 7.516 0.065 16.55 19.64 3.84 21.9
IL-33 0.31 251.58 285.6 0.18 156.1 190.2 0.18 359.4 499.1 0.002 521.8 2016.4 0.364 1.85
Hippocampus Median (pg/ml) Median (pg/ml) Median (pg/ml) Median (pg/ml)   
2mo 4mo 8mo 18mo
P value WT APP KI   P value WT APP KI   P value WT APP KI   P value WT APP KI  
IL-5 0.18 0.389 0.468 0.093 0.411 0.496 0.24 0.214 0.231 0.394 0.518 0.54 0.06 302
IL-4 0.998 0.378 0.39 0.394 0.335 0.372 0.307 0.188 0.202 0.784 0.366 0.36 0. 11 0.818
IL-10 NA NA NA   NA NA NA   NA NA NA   NA NA NA   0.9.4 7.26
IL-27p28/1L-30 0.132 12.79 15.96 0.937 12.52 13.47 0.178 5.8 7.724 0.041 20.38 24.69 1.39 5.91
TNF-α 0.065 0.201 0.282 0.084 0.258 0.319 0.191 0.13 0.198 0.002 0.413 1.126 0.13 0.98
KC-GRO 0.18 5.067 6.519 0.002 14.14 5.7 0.394 3.548 5.757 0.009 8.711 14.45 0. 24 3.29
IL-1β 0.31 0.32 0.387 0.026 0.369 0.509 0.24 0.277 0.44 0.002 0.851 3.053 0.11 0.72
IL-6 0.165 11.87 15.05 0.18 13.9 16.86 0.792 5.006 5.566 0.18 17.02 19.71 0.61 7.61
IL-2 0.455 0.666 0.757 0.699 0.614 0.659 0.571 0.282 0.315 0.937 0.726 0.754 0.22 1.03
IL-12p70 0.394 46.42 49.82 0.699 45.81 46.28 0.571 9.232 11.074 0.784 56.46 53.27 9.95 179
IFN-y 0.288 0.241 0.253 0.104 0.211 0.25 0.485 0.147 0.158 0.197 0.262 0.279 0.04 390
MIP-2 0.31 0.861 0.942 0.041 2.505 1.216 0.31 0.517 0.991 0.002 2.466 4.595 0.053 0.58
IP-10 0.31 9.215 8.406 0.699 9.973 10.34 0.004 3.636 15.35 0.002 12.49 88.79 328 2.15
MIP-1α 0.589 3.414 3.968 0.002 3.416 19.48 0.002 1.928 54.22 0.002 9.231 304.9 0.081 0.38
IL-15 0.24 154.9 172.6 0.818 190.5 166.9 0.931 69.34 80.13 0.026 254.8 322.1 16 43.2
IL-17A/F 0.041 4.377 5.543 0.31 8.042 6.996 0.444 1.652 2.184 0.002 9.737 13.16 0.231 1.39
MCP-1 0.818 23.81 25.46 0.589 27.97 26.96 0.485 16.35 22.25 0.015 33.78 45.04 672 4.42
IL-9 0.065 7.477 11.28 0.937 13.36 14.05 0.485 8.438 10.31 0.169 18.89 21.93 3. 84 21.9
IL-33 0.24 231.3 294.7 0.041 305.9 457.7 0.132 294.2 457 0.002 1030 2473 0.364 1 _85