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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

Fig. 3

Alterations in LM receptor levels. The levels of BLT1, ChemR23, LGR6, GPR18 and FPR2, receptors for pro-resolving lipid mediators (LMs), in cortex and hippocampus of WT and App KI mice aged 2, 4, 8 and 18 months were determined by Western blot analysis. (a) Representative blots and (b) quantitative analysis are shown. Results are mean ± SEM and analysed by Mann–Whitney U test (#P < 0.05, ##P < 0.01, ###P < 0.001) for intergroup analysis. Kruskal–Wallis one-way analysis of variance test with Dunn’s post hoc test (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001) was used for multiple comparisons between ages and genotypes. AA = arachidonic acid, BLT1 = leukotriene B4 receptor, ChemR23 = chemokine like receptor 1, DHA = docosahexaenoic acid, EPA = eicosapentaenoic acid, FPR2 = formyl peptide receptor 2, GPR18 = G-protein coupled receptor 18, LGR6 = leucine-rich repeat containing G-protein coupled receptor 6

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