Skip to main content
Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Fig. 8

CSF1R inhibition attenuates amyloid-facilitated tau-seeded pathology and neurodegeneration. a Quantitative analysis of W02 signal in the cortex and hippocampus of PLX3397 treated tau-seeded F+/T+ mice (n = 6) compared to non-treated tau-seeded F+/T+ mice (n = 8) and non-seeded littermates (n = 9). b Quantitative analysis of AT8 signal in the cortex and hippocampus of PLX3397 treated tau-seeded F+/T+ mice (n = 6) compared to non-treated tau-seeded F+/T+ mice (n = 8 Cx, n = 9 HC) and non-seeded littermates (n = 9). Analyses were done at 7 months of age (3 months post-injection). Data are presented as mean ± SEM; *p < 0.05; **p < 0.01; ***p < 0.001 ****p < 0.0001. one-way ANOVA, Dunnett’s multiple comparison test. c Representative images of frontal cortex (scale bar = 250 µm) and hippocampus (scale bar = 500 µm) of PLX3397 treated tau-seeded F+/T+ mice, non-treated tau-seeded F+/T+ mice and non-seeded littermates at 7 months (3 months post-injection), immunohistochemically stained with anti-phospho-tau (pSer202/Thr205) antibody. d Quantification of cortical area and hippocampal volume in PLX3397 treated tau-seeded F+/T+ mice (n = 6) compared to non-treated tau-seeded F+/T+ mice (Cx n = 8, HC n = 9) and non-seeded littermates (n = 9). Data are presented as mean ± SEM; *p < 0.05; **p < 0.01; ***p < 0.001 ****p < 0.0001. one-way ANOVA, Dunnett’s multiple comparison test. FrCx = frontal cortex; HC = hippocampus

Back to article page