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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Fig. 3

ATN pathology exacerbates microgliosis. a, b Representative images of (a) frontal cortex (Scale bar = 250 µm) and (b) hippocampus (Scale bar = 500 µm) of wildtype F/T, F+/T and tau-seeded F+/T+ mice at 7 months of age, immunohistochemically stained with anti-Aβ antibody W02, anti-phospho-tau (pSer202/Thr205) antibody AT8 and anti-Iba1 antibody. Quantitative analysis of W02, AT8 and Iba1 signal in F/T (n = 6), F+/T (n = 6) and tau-seeded F+/T+ (n = 6) mice. One-way ANOVA with Tukey’s multiple comparison test (normally distributed); Kruskal–Wallis test with Dunn’s multiple comparison (non-normally distributed). Data are presented as mean ± SEM; *p < 0.05; ***p < 0.001; ****p < 0.0001

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