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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

Fig. 2

Amyloid pathology aggravates tau-induced atrophy. a Representative images of the hippocampus of tau-seeded F/T+ and F+/T+ mice and their non-seeded littermates at 7 months (3 months post-injection), immunohistochemically stained with anti-NeuN antibody. Scale bar = 500 µm. b Quantification of hippocampal area and hippocampal volume of tau-seeded F+/T+ mice (n = 6) compared to tau-seeded F/T+ mice (n = 8) and non-seeded F/T+ and F+/T+ mice (area: n = 9; n = 9). Two-way ANOVA, Tukey’s test for multiple comparison. Data are presented as mean ± SEM; **p < 0.01; ***p < 0.001; ****p < 0.0001 c Correlation analysis between tau pathology in the hippocampus and hippocampal atrophy in 7 months old tau-seeded and non-seeded F/T+ and F+/T+ mice. Pearson’s correlation analysis

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