Table 2 Genome-wide significant variants associated with CAA in AD cases identified at a novel locus LINC-PINT and the APOE locus
SNP ID | CHR | Position | Closest Gene | Function | A1 | MAF | HWE p-value | APOE ε4 -ve | APOE ε4 + ve | All | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BETA (95% CI) | p-value | BETA (95% CI) | p-value | BETA (95% CI) | p-value | ||||||||
rs10234094 | 7 | 130,691,759 | LINC-PINT | ncRNA_intronic | C | 0.09 | 5.10E-01 | − 0.37 (-0.49—− 0.24) | 1.63E-08 | 0.04 (-0.04—0.13) | 3.02E-01 | − 0.11 (-0.18—-0.03) | 5.72E-03 |
rs5117 | 19 | 45,418,790 | APOC1 | intronic | C | 0.41 | 2.73E-01 | 0.23 (0.04—0.42) | 1.92E-02 | 0.30 (0.37—0.23) | 8.54E-15 | 0.19 (0.15—0.23) | 9.42E-18 |
rs429358 | 19 | 45,411,941 | APOE | exonic | C | 0.39 | 1.89E-01 | 0.57 (− 0.06—1.19) | 7.55E-02 | 0.32 (0.40—0.25) | 9.35E-16 | 0.18 (0.14—0.23) | 1.66E-16 |