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Table 2 Genome-wide significant variants associated with CAA in AD cases identified at a novel locus LINC-PINT and the APOE locus

From: Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

SNP ID CHR Position Closest
Gene
Function A1 MAF HWE
p-value
APOE ε4 -ve APOE ε4 + ve All
BETA
(95% CI)
p-value BETA
(95% CI)
p-value BETA (95% CI) p-value
rs10234094 7 130,691,759 LINC-PINT ncRNA_intronic C 0.09 5.10E-01 − 0.37 (-0.49—− 0.24) 1.63E-08 0.04 (-0.04—0.13) 3.02E-01 − 0.11 (-0.18—-0.03) 5.72E-03
rs5117 19 45,418,790 APOC1 intronic C 0.41 2.73E-01 0.23 (0.04—0.42) 1.92E-02 0.30 (0.37—0.23) 8.54E-15 0.19 (0.15—0.23) 9.42E-18
rs429358 19 45,411,941 APOE exonic C 0.39 1.89E-01 0.57 (− 0.06—1.19) 7.55E-02 0.32 (0.40—0.25) 9.35E-16 0.18 (0.14—0.23) 1.66E-16