Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease

Fig. 2

rTMS decreases Aβ accumulation in the 5xFAD brains. a Representative images of Aβ and NeuN immunofluorescence staining in the mPFC, the DG, CA3 and CA1 subregions of dorsal hippocampus and the S1 cortex. Coronal positions of the brain sections shown on the top corresponds to the immunofluorescence staining results below. Red: 6E10 staining. Green: NeuN staining. Scale bar: 200 μm. b Quantitative analyses of Aβ fluorescence intensity within the NeuN-positive cells (intraneuronal Aβ) across different regions, comparing 5xFAD mice received sham treatment (AD-Ctrl) and 5xFAD mice received rTMS treatment (AD-rTMS) (n = 8–13 mice per group). c Quantitative analyses of the density of extracellular plaque-like Aβ deposits across different regions, comparing AD-Ctrl and AD-rTMS groups (n = 8–13 mice per group). All data are presented as mean ± SEM and analyzed by unpaired two-tailed Student’s t-test. mPFC: medial prefrontal cortex, DG: dentate gyrus, CA3: cornu ammonis 3, CA1: cornu ammonis 1, S1: primary sensory cortex

Back to article page