Fig. 4
From: Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
Cognitive impairment induced by hTAUP301L overexpression is prevented in Cnr2−/− mice. a Recognition memory was tested by NOR test in control mice (Sham), and Cnr2+/+ and Cnr2−/− mice overexpressing hTAUP301L (n = 8–15 per experimental group). b qRT-PCR determination of mRNA levels of Bdnf, normalized by Tbp mRNA levels, n = 5–7 samples ± SEM. Asterisks denote significant differences with *p < 0.05, comparing each group with the contralateral hippocampi from Cnr2+/+ mice or the indicated groups, according to two-way ANOVA followed by Bonferroni post-test. Reduction in the granular cell layer from the dentate gyrus due to hTAUP301L overexpression is attenuated in Cnr2−/− mice. c Quantification of the area stained with DAPI (arbitrary units) in the dentate gyrus from Cnr2+/+ and Cnr2−/− mice injected with AAV-hTAUP301L. n = 3–4 samples ± SEM. Asterisks denote significant differences with *p < 0.05 comparing the ipsilateral side with the contralateral side of the indicated groups, according to two-way ANOVA followed by Bonferroni post-test. d Immunofluorescence staining in hippocampal sections from Cnr2+/+ and Cnr2−/− mice injected with AAV-hTAUP301L (n = 3–4 per experimental group). Blue, DAPI. Green, anti-CALBINDIN-D28K