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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Zika virus induces neuronal and vascular degeneration in developing mouse retina

Fig. 8

NITD008 treatment blocks ZIKV-induced retinal abnormalities. ZIKV was injected into neonatal mice at P0, followed by NITD008 treatment right after ZIKV infection and every other day until day 12, and retinas were collected at P14. a Representative images of PI-stained retinal sections at P14. Graph represents the thickness of total retina from GCL to ONL. n = 12–13 per group. b Representative images of retinal flatmounts labeled with CD31 (green) for vasculature. cf Representative images of retinal flatmounts labeled with anti-Tuj1 for RGCs, anti-GFAP for astrocytes, anti-Iba1 for microglia, and anti-CD45 for leukocytes. n = 4–8 per group. Scale bar = 50 μm except the upper panel in b where scale bar = 500 μm. Data are presented as mean ± S.E.M. ****p < 0.0001 compared to control mice

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