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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: The degree of astrocyte activation is predictive of the incubation time to prion disease

Fig. 5

A relationship between the changes in the expression of gene sets in cortex. (a) Heat map of directed global significance scores for 20 gene sets across 19 groups of animal samples. (b) A strong correlation between the sum of undirected global significance scores of the gene sets reporting on the degree of astrocyte activation (A1-, A2-, pan-specific markers and other markers of reactive astrocytes) and dysregulation of astrocyte function (BBB regulation, channels, lipid/cholesterol homeostasis, myelination, energy metabolism, extracellular matrix, gliotransmitters, transporters, glutamate-glutamine cycle, neuroprotection, neurotoxicity)

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