Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Table 2 Summary of data from seeding Thy1-G93A Line T3 mice and VLE-G93A

Host	Inoculum (Route)	# inoculated^a	# paralyzed	Age to paralysis or euthanasia
Thy1-G93A	PBS	2	0	14.8, 16.6 mo
Thy1-G93A	NTg Sp Cord (ISP)	3	0	17.7, 18.2, 19.1 mo
Thy1-G93A	Gur G93A Sp Cord (ISP)	4	0	Terminated at 19 mo
Thy1-G93A	G37R-L29 Sp Cord (ISP)	4	0	Terminated at 18 mo
VLE-G93A	G93A(FVB) Sp Cord (ISP)	8	3	5.3, 8.3, 13.4
VLE-G93A	G93A(FVB) Sp Cord (ScN)	11	3	5.8, 8, 10
VLE-G93A	PBS (ScN)	5	0	Terminated at 12 mo

^aMice that were euthanized for non-MND related conditions, such as fight wounds or tumors, before 12 months of age were excluded, unless otherwise noted

ISSN: 2051-5960