Table 1 Summary of data for recombinant SOD1 protein seeding experiments
SOD1 protein | Avg survival time in yearsa | Fibrils visible by EM | Induced pathology in G85R-SOD1:YFP slice culture |
|---|---|---|---|
bWT | N/A | Yes | Yes |
A4V | 1.2 ± 0.9 | Yes | Yes |
G37R | 18.7 ± 11.4 | Yes | Yes |
G41S | 0.9 ± 0.2 | No | Yes |
H46R | 17.0 ± 7 | Yes | Yes |
G85R | 6.0 ± 4.5 | N.D | Yes |
G93C | 13.0 ± 0.4 | Yes | Yes |
E100K | 12.0 ± 4.1 | Yes | Yes |
D101N | 2.4 ± 0.9 | No | Yes |