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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Fig. 6

Induction of G85R-SOD1:YFP inclusion pathology by co-expression of untagged mutant SOD1. ac Kaplan–Meier survival curves and representative pathologic images resulting from G85R-SOD1:YFP mice crossed with mice expressing untagged L126Z (Line 45) (L126Z mice n = 3, G85R-YFP mice n = 5, L45xG85R-YFP mice n = 6); untagged G37R (Line 29) (G37R mice n = 6, G85R-YFP mice n = 10, L29xG85R-YFP mice n = 6), or untagged WT human SOD1 (GurWT n = 14, G85R-YFP n = 5, GurWTxG85R-YFP n = 8), respectively. Survival plots in this figure and figures that follow were generated in GraphPad Prism v9. Representative images of inclusion pathology seen in cryostat sections from the spinal cord of paralyzed bigenic mice created in each crossing experiment (images representative of 2–3 sections per mouse). Scale bars = 50 µm

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