Fig. 2
Variability in seeding efficiency of spinal homogenates from paralyzed G93A SOD1 mice in G85R-SOD1:YFP mice. a Scatter plot of the ages at which G85R-SOD1:YFP mice developed paralysis or were euthanized after injection of spinal homogenates. TgG93A denotes spinal homogenate from paralyzed GurG93A mice. P1-G93AG85R−SOD1:YFP denotes inoculum from a paralyzed first-passage G85R-SOD1:YFP animal. b–d Representative images of inclusion pathology in cryostat sections induced in the spinal cord of G85R-SOD1:YFP mice that had been injected with spinal homogenates from G93A mice with subsequent passages (images representative of 2–3 sections per mouse). Raw data provided in Additional file 1: Data File 1. Scale bars = 50 µm