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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Early onset senescence and cognitive impairment in a murine model of repeated mTBI

Fig. 4

rmTBI brains have increased expression of GFAP at 1 day (b) and 7 days (c) post-injury, compared to shams (a) in the impact region of the isocortex, indicating gliosis. Microglial activation, shown with Iba1 staining, can be seen in rmTBI brains at both 1 day (e) and 7 days (f) post-injury compared to shams (d). At 7 days post-injury rmTBI mice showed evidence of axonal damage by the presence of APP positive spheroids in the subcortical white matter (h), which was not present in shams (i, low power view in g). Scale bars: 0.3 mm in af, 0.1 mm in g, 0.05 mm in h, 0.08 mm in i

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