Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Early onset senescence and cognitive impairment in a murine model of repeated mTBI

Fig. 2

rmTBI mice show evidence of spatial learning and memory impairment at 1 week post-injury. a rmTBI mice swam an average of 1.8 cm/s faster than sham mice. b Across three training days rmTBI mice had a significantly increased latency to find the platform compared to shams (p < 0.001, main effect of injury status, repeated measures ANOVA). c In the probe test rmTBI mice spent less time in the platform zone compared to shams (p = 0.55, Mann–Whitney U Test). Analysis of search strategies with Rtrack revealed no significant differences one training day one, however rmTBI mice used significantly different search strategies by training days two (χ2 = 6.2, df = 2, p = 0.05) and three (χ2 = 33.9, df = 2, p < 0.0001) with rmTBI mice utilizing less allocentric strategies than shams by the end of training

Back to article page