Fig. 6
From: Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
Distinct types of Aβ42 pathology in AppNL−F mice inoculated with recombinant Aβ43 aggregates or purified AppNL−F Aβ aggregates. a Cerebellar Aβ42 deposition (12F4 immunostaining) in an AppNL−F mouse at 6 months post-inoculation with recombinant Aβ43 aggregates. b–d Leptomeningeal Aβ42 deposition in Aβ43-inoculated mice at the interface between cerebellar folds (b), at the interface between the cerebellum and the midbrain (c), and at the interface between the cortex and the midbrain (d). e Spreading of Aβ42 pathology into the frontal cortex of an AppNL−F mouse at 6 months post-inoculation with purified AppNL−F Aβ aggregates. f Spreading of Aβ42 pathology into the occipital cortex of a mouse inoculated with purified AppNL−F Aβ aggregates. g Diffuse Aβ42 plaque in the occipital cortex of a mouse inoculated with purified AppNL−F Aβ aggregates. Scale bars = 500 µm (a), 20 µm (b–d, g), 200 µm (e), or 100 µm (f)