Fig. 4

Induction of protease-resistant Aβ species in the brains of Aβ43-inoculated App^NL−F mice. a Levels of PK-resistant Aβ42 were not significantly different from levels of total Aβ42 in mice injected with recombinant Aβ43 aggregates (n = 8; P = 0.91 by a paired two-tailed t test). Open circles indicate female mice and filled circles indicate male mice. b Immunoblot of insoluble, PK-resistant Aβ species in brain homogenates from App^NL−F mice inoculated with either dH₂O or PK-resistant recombinant Aβ38, Aβ40, Aβ42, or Aβ43 aggregates. Aβ was detected using the antibodies 6E10 or 82E1. c Immunoblot of insoluble, PK-resistant Aβ species in brain homogenates from App^NL−F mice inoculated with either non-Tg sample, TgCRND8 Aβ aggregates, or App^NL−F Aβ aggregates. Aβ was detected using the antibody 82E1