Skip to main content

Table 1 DIPG and GBM cell models used in studies

From: Design considerations of an IL13Rα2 antibody–drug conjugate for diffuse intrinsic pontine glioma

Article Model Name DIPG-6 DIPG-17 DIPG-24 SF-8628 CHLA-200
Official Name SU-DIPG-VI SU-DIPG-XVII SU-DIPG-24 SF8628 CHLA-200
Accession ID CVCL_IT40 N/A N/A CVCL_IT46 CVCL_M147
IL13Rα2 Status IL13Rα2-High IL13Rα2-High IL13Rα2-Low IL13Rα2-High IL13Rα2-High
Model Type Neurosphere Culture (suspension) Neurosphere Culture (suspension) Neurosphere Culture (generally adherent) Cell Line (adherent) Cell Culture (adherent)
Growth Media Complete TSM Complete TSM Complete TSM DMEM + 1% P/S + 10% FBS IMDM + 1% P/S + 20% FBS + 4 mM L-Glut + 1× ITS
Age at diagnosis (years) 7 8 6 5 12
Gender Female Male Female Female Male
Histology HGG DIPG DIPG DIPG GBM
H3 status H3.3K27M H3.3K27M H3.3K27M H3.3K27M Unknown
Grade III IV IV IV IV
Origin Pons Pons Pons Unknown Parietal lobe
Treatment XRT + vorinostat XRT + bevacizumab; panobinostat—> XRT—> everolimus XRT + bevacizumab Unknown XRT + chemotherapy
Survival (months) 6 13 8 Unknown Unknown
Tissue Source autopsy autopsy autopsy surgical biopsy autopsy
Material Source Monje Lab Monje Lab Monje Lab EMD Millipore COG Repository
PMID 25939062[25] 28823557[47] 28823557[47] 23603901[13] 22120608[54]