From: Combined epigenetic/genetic study identified an ALS age of onset modifier
Sample characteristics | DNAm analysis (n = 249) | Genotyping analysis (n = 469) | Replication cohort (n = 4160) |
---|---|---|---|
Familial ALS (n, %) | 49, 19.6% | 68, 14.5% | 415, 10.0% |
Sporadic ALS (n, %) | 200, 80.3% | 401, 85.5% | 3745, 90% |
Sex, male (n, %) | 148, 59.4% | 280, 59.7% | 2517, 60.5% |
Median age of onset (interquartile range), years | 60 (51–69) | 61 (52–68) | 58 (49–66) |
Bulbar site of onset (n) | 67 | 112 | 990 |
Limb site of onset (n) | 172 | 314 | 2882 |