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Table 1 Sample characteristics for unrelated ALS patients included in the DNA methylation (DNAm) study, and genotyping analysis of candidate variants in discovery and replication stage

From: Combined epigenetic/genetic study identified an ALS age of onset modifier

Sample characteristics

DNAm analysis (n = 249)

Genotyping analysis (n = 469)

Replication cohort (n = 4160)

Familial ALS (n, %)

49, 19.6%

68, 14.5%

415, 10.0%

Sporadic ALS (n, %)

200, 80.3%

401, 85.5%

3745, 90%

Sex, male (n, %)

148, 59.4%

280, 59.7%

2517, 60.5%

Median age of onset (interquartile range), years

60 (51–69)

61 (52–68)

58 (49–66)

Bulbar site of onset (n)

67

112

990

Limb site of onset (n)

172

314

2882