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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Combined epigenetic/genetic study identified an ALS age of onset modifier

Fig. 3

The association between rs4970944 and ALS age of onset. a Genotypes of rs4970944 are significantly associated with age of onset in the discovery cohort of 469 Canadian ALS patients (P = 0.025, adjusted for sex, site of onset and family history, B = 2.0, SE = 0.9). Each A-allele is associated with a 2-year later onset. b Genotypes of rs4970944 are significantly associated with age of onset in the replication cohort of 4160 US ALS patients (P = 0.007, adjusted for sex, site of onset and family history; B = 0.8, SE = 0.3). Each A-allele is associated with a 0.8-year later onset. c Meta-analysis of the adjusted regression coefficient from the discovery cohort (n = 469) and the replication cohort (n = 4160) confirmed the significant association between rs4970944 and ALS age of onset (pooled B = 0.9, P = 0.0012)

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