From: Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Gene Set | SIZE | NES | P-value | FDR | Relevance to AD |
---|---|---|---|---|---|
Top 10 GO Biological Process terms in females | |||||
INTEGRIN_ACTIVATION | 24 | 2.105 | 0 | 9.53E−02 | Wennstrome et al. [98] |
RESPONSE_TO_PLATELET_DERIVED_GROWTH_FACTOR | 19 | 2.116 | 0 | 1.07E−01 | Sil et al. [99] |
I_KAPPAB_PHOSPHORYLATION | 19 | 2.081 | 0 | 1.13E−01 | Jha et al. [100] |
NEGATIVE_REGULATION_OF_INTERLEUKIN_8_PRODUCTION | 18 | 2.133 | 0 | 1.21E−01 | Qin et al. [101] |
POSITIVE_REGULATION_OF_MACROPHAGE_MIGRATION | 25 | 2.048 | 0 | 1.46E−01 | Bacher et al. [102] |
TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 142 | 2.031 | 0 | 1.61E−01 | Fiebich et al. [103] |
NEGATIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION | 57 | 2.007 | 0 | 1.90E−01 | Chang et al. [104] |
REGULATION_OF_SYNCYTIUM_FORMATION_BY_PLASMA_MEMBRANE_FUSION | 28 | 1.944 | 0 | 1.98E−01 | Armoto et al. [105] |
RESPONSE_TO_VITAMIN_A | 19 | 1.945 | 0 | 2.08E−01 | Ono et al. [106] |
POSITIVE_REGULATION_OF_AXON_EXTENSION | 42 | 1.931 | 0 | 2.08E−01 | Kanaan et al. [107] |
Top 10 Biological Process terms in males | |||||
REGULATION_OF_T_CELL_ACTIVATION_VIA_T_CELL_RECEPTOR_CONTACT_WITH_ANTIGEN_BOUND_TO_MHC_MOLECULE_ON_ANTIGEN_PRESENTING_CELL | 6 | 1.869 | 0 | 5.98E−01 | Schetters et al. [108] |
REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE_BY_CIRCULATORY_RENIN_ANGIOTENSIN | 18 | 1.964 | 0 | 6.11E−01 | Cosarderelioglu et al. [57] |
NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS | 29 | 1.745 | 0 | 6.12E−01 | Manoharan et al. [59] |
COMPLEMENT_ACTIVATION | 68 | 1.741 | 0 | 6.26E−01 | Morgan [97] |
RESPONSE_TO_ANGIOTENSIN | 26 | 1.746 | 0 | 6.36E−01 | Benigni et al. [58] |
CELL_REDOX_HOMEOSTASIS | 55 | 1.721 | 0 | 6.49E−01 | Chen et al. [60] |
PROTEIN_DEMETHYLATION | 28 | 1.832 | 0 | 6.77E−01 | Esposito et al. [109] |
IMMUNE_RESPONSE_INHIBITING_CELL_SURFACE_RECEPTOR_SIGNALING_PATHWAY | 6 | 1.781 | 0 | 7.02E−01 | Schetters et al. [108] |
DICARBOXYLIC_ACID_CATABOLIC_PROCESS | 17 | 2.052 | 0 | 7.57E−01 | Griffin et al. [110] |
GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS | 70 | 1.657 | 0 | 7.75E−01 | Conway et al. [111] |