From: Sex-specific DNA methylation differences in Alzheimer’s disease pathology
cpg | Annotations | Female samples | Male samples | Sex * Braak stage interaction | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
chr | Position | Illumina | GREAT (distance to TSS) | chromatin state | estimate | se | P-value | estimate | se | P-value | estimate | se | P-value | adj.pval | |
cg13212831 | chr1 | 56046343 | USP24(-365558); PPAP2B(+ 998897) | Weak transcription | 0.083 | 0.030 | 6.15E-03 | − 0.139 | 0.034 | 4.10E-05 | − 0.222 | 0.044 | 6.38E-07 | 3.54E-04 | |
cg25734825 | chr3 | 119182523 | TMEM39A | TMEM39A(+ 5) | Active TSS | 0.059 | 0.030 | 5.01E-02 | − 0.156 | 0.036 | 1.21E-05 | − 0.220 | 0.045 | 1.12E-06 | 6.22E-04 |
*cg02331272 | chr11 | 66964208 | KDM2A;KDM2A | ADRBK1(-69672); KDM2A(+ 77051) | Weak transcription | 0.058 | 0.030 | 1.10E-01 | − 0.166 | 0.036 | 2.99E-06 | − 0.215 | 0.046 | 2.25E-06 | 1.25E-03 |
cg10622825 | chr1 | 172413349 | PIGC;PIGC;C1orf105 | PIGC(-124) | Active TSS | − 0.069 | 0.030 | 2.22E-02 | 0.134 | 0.034 | 7.78E-05 | 0.200 | 0.045 | 7.00E-06 | 3.88E-03 |
cg10784067 | chr16 | 14014435 | ERCC4 | ERCC4(+ 422) | Active TSS | − 0.127 | 0.032 | 5.33E-05 | 0.068 | 0.033 | 3.78E-02 | 0.201 | 0.045 | 9.03E-06 | 5.01E-03 |
cg14284055 | chr1 | 24439399 | MYOM3 | MYOM3(-735) | Bivalent Enhancer | 0.115 | 0.029 | 8.28E-05 | − 0.066 | 0.037 | 7.12E-02 | − 0.193 | 0.045 | 1.94E-05 | 1.07E-02 |
*cg18942110 | chr15 | 91072797 | CRTC3;CRTC3 | CRTC3(-502) | Active TSS | 0.031 | 0.030 | 3.06E-01 | − 0.164 | 0.035 | 2.23E-06 | − 0.187 | 0.045 | 3.13E-05 | 1.74E-02 |
cg09342330 | chr14 | 89021109 | PTPN21;PTPN21 | PTPN21(-33) | Active TSS | 0.045 | 0.030 | 1.31E-01 | − 0.144 | 0.037 | 8.30E-05 | − 0.189 | 0.046 | 3.47E-05 | 1.93E-02 |
cg21722170 | chr6 | 31977443 | TNXB;TNXA | C4B(-5095); C4A(+ 27643) | Quiescent/Low | 0.034 | 0.030 | 2.53E-01 | − 0.148 | 0.034 | 1.57E-05 | − 0.183 | 0.045 | 4.17E-05 | 2.31E-02 |
cg03662217 | chr21 | 35747882 | FAM165B | SMIM11(-20) | Active TSS | 0.039 | 0.029 | 1.85E-01 | − 0.141 | 0.036 | 7.27E-05 | − 0.184 | 0.045 | 4.59E-05 | 2.55E-02 |
cg15026265 | chr12 | 28283812 | PTHLH(-158910); CCDC91(-59566) | Quiescent/Low | − 0.038 | 0.029 | 1.95E-01 | 0.134 | 0.033 | 6.58E-05 | 0.176 | 0.044 | 6.72E-05 | 3.73E-02 | |
cg00659421 | chr7 | 86781760 | DMTF1;DMTF1;DMTF1;DMTF1;DMTF1;DMTF1;DMTF1 | DMTF1(-109) | Active TSS | − 0.050 | 0.031 | 1.08E-01 | 0.130 | 0.033 | 7.53E-05 | 0.178 | 0.045 | 6.95E-05 | 3.86E-02 |
*cg24917065 | chr8 | 23418389 | SLC25A37 | SLC25A37(+ 32072); NKX3-1(+ 122050) | Quiescent/Low | − 0.135 | 0.030 | 6.26E-06 | 0.042 | 0.033 | 2.05E-01 | 0.174 | 0.044 | 6.98E-05 | 3.87E-02 |
*cg18281939 | chr5 | 77783895 | LHFPL2 | SCAMP1(+ 127557); LHFPL2(+ 160752) | Weak transcription | − 0.022 | 0.029 | 4.55E-01 | − 0.179 | 0.036 | 6.26E-07 | − 0.177 | 0.045 | 7.10E-05 | 3.94E-02 |