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Table 3 Association of insulin signaling measures with cerebral vessel pathologies

From: Brain insulin signaling and cerebrovascular disease in human postmortem brain

 

OR, Estimate (SE, p)

Atherosclerosis

Arteriolosclerosis

Amyloid angiopathy

ELISA

 pS307IRS1/total IRS1

0.748, − 0.290 (0.1662, 0.081)

1.073, 0.071 (0.160, 0.658)

0.801, − 1.222 (0.163, 0.174)

 pT308AKT1/total AKT1

1.041, 0.040 (0.160, 0.803)

1.279, 0.246 (0.157, 0.118)

1.104, 0.099 (0.160, 0.537)

Immunohistochemistry

 IRS1 cells/mm2

1.280, 0.246 (0.175, 0.159)

0.794, − 0.231 (0.172, 0.179)

1.354, 0.303 (0.1683, 0.934)

Ex vivo stimulation

 IRS1 recruitment to IRβ

1.365, 0.311 (0.228, 0.171)

1.199, 0.182 (0.213, 0.403)

0.900, − 0.106 (0.229, 0.644)

 pS473AKT1

1.048, 0.048 (0.223, 0.834)

1.206, 0.187 (0.219, 0.392)

0.496, − 0.701 (0.253, 0.006)

 pT308AKT1

1.215, 0.1951 (0.220, 0.375)

1.115, 0.109 (0.216, 0.613)

0.643, − 0.442 (0.231, 0.055)

 pY1150/1151IRβ

1.353, 0.3025 (0.2293, 0.187)

1.295, 0.258 (0.222, 0.245)

0.994, − 0.006 (0.234, 0.979)

 pY960IRβ

1.117, 0.111 (0.221, 0.615)

1.337, 0.290 (0.218, 0.182)

0.573, − 0.557 (0.242, 0.021)

  1. Separate age and sex adjusted ordinal logistic regression models, for each categorical cerebral vessel pathology outcome measure (see text for methods, including categorizing vessel pathology into 3 ordinal levels); results which reach statistical significance are in bold (see methods for corrections for multiple comparisons)
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Acta Neuropathologica Communications

ISSN: 2051-5960

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