Table 2 Association of insulin signaling measures with brain infarcts
From: Brain insulin signaling and cerebrovascular disease in human postmortem brain
OR, Estimate (SE, p) | |||||
|---|---|---|---|---|---|
Any infarct | Size of infarct | Location of infarct | |||
Gross infarcts | Microinfarcts | Cortical infarcts | Subcortical infarcts | ||
ELISA | |||||
pS307IRS1/total IRS1 | 0.689, − 0.375 (0.169, 0.027) | 0.718, − 0.331 (0.190, 0.081) | 0.708, − 0.346 (0.195, 0.076) | 0.828, − 0.188 (1.206, 0.361) | 0.735, − 0.308 (0.185, 0.096) |
pT308AKT1/total AKT1 | 1.282, 0.248 (0.159, 0.120) | 1.321, 0.279 (0.176, 0.114) | 1.135, 0.127 (0.178, 0.477) | 1.207, 0.188 (0.189, 0.320) | 1.319, 0.277 (0.174, 0.112) |
Immunohistochemistry | |||||
IRS1 cells/mm2 | 1.137, 0.129 (0.160, 0.423) | 1.017, 0.017 (0.177, 0.925) | 1.371, 0.315 (0.183, 0.085) | 1.200, 0.183 (0.181, 0.314) | 1.058, 0.056 (0.175, 0.7469) |
Ex vivo stimulation | |||||
IRS1 recruitment to IRβ | 1. 549, 0.438 (0.230, 0.057) | 1.245, 0.219 (0.246, 0.372) | 1.434, 0.361 (0.255, 0.158) | 1.606, 0.474 (0.279, 0.090) | 1.252, 0.225 (0.244, 0.356) |
pS473AKT1 | 1.536, 0.429 (0.231, 0.063) | 1.453, 0.373 (0.254, 0.142) | 1.350, 0.300 (0.259, 0.246) | 2.158, 0.769 (0.313, 0.014) | 1.204, 0.188 (0.244, 0.446) |
pT308AKT1 | 1.916, 0.650 (0.240, 0.007) | 1.940, 0.663 (0.276, 0.016) | 1.426, 0.355 (0.255, 0.164) | 1.758, 0.564 (0.290, 0.052) | 1.575, 0.454 (0.256, 0.076) |
pY1150/1151IRβ | 1.193, 0.177 (0.225, 0.433) | 1.070, 0.068 (0.247, 0.784) | 1.074, 0.071 (0.256, 0.781) | 1.562, 0.446 (0.297, 0.133) | 0.979, − 0.0.1 (0.243, 0.930) |
pY960IRβ | 1.604, 0.473 (0.229, 0.039) | 1.319, 0.277 (0.244, 0.256) | 1.518, 0.417 (0.259, 0.108) | 1.667, 0.511 (0.286, 0.074) | 1.397, 0.334 (0.245, 0.173) |