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Table 2 Association of insulin signaling measures with brain infarcts

From: Brain insulin signaling and cerebrovascular disease in human postmortem brain

  OR, Estimate (SE, p)
Any infarct Size of infarct Location of infarct
Gross infarcts Microinfarcts Cortical infarcts Subcortical infarcts
ELISA
 pS307IRS1/total IRS1 0.689, − 0.375 (0.169, 0.027) 0.718, − 0.331 (0.190, 0.081) 0.708, − 0.346 (0.195, 0.076) 0.828, − 0.188 (1.206, 0.361) 0.735, − 0.308 (0.185, 0.096)
 pT308AKT1/total AKT1 1.282, 0.248 (0.159, 0.120) 1.321, 0.279 (0.176, 0.114) 1.135, 0.127 (0.178, 0.477) 1.207, 0.188 (0.189, 0.320) 1.319, 0.277 (0.174, 0.112)
Immunohistochemistry
 IRS1 cells/mm2 1.137, 0.129 (0.160, 0.423) 1.017, 0.017 (0.177, 0.925) 1.371, 0.315 (0.183, 0.085) 1.200, 0.183 (0.181, 0.314) 1.058, 0.056 (0.175, 0.7469)
Ex vivo stimulation
 IRS1 recruitment to IRβ 1. 549, 0.438 (0.230, 0.057) 1.245, 0.219 (0.246, 0.372) 1.434, 0.361 (0.255, 0.158) 1.606, 0.474 (0.279, 0.090) 1.252, 0.225 (0.244, 0.356)
 pS473AKT1 1.536, 0.429 (0.231, 0.063) 1.453, 0.373 (0.254, 0.142) 1.350, 0.300 (0.259, 0.246) 2.158, 0.769 (0.313, 0.014) 1.204, 0.188 (0.244, 0.446)
 pT308AKT1 1.916, 0.650 (0.240, 0.007) 1.940, 0.663 (0.276, 0.016) 1.426, 0.355 (0.255, 0.164) 1.758, 0.564 (0.290, 0.052) 1.575, 0.454 (0.256, 0.076)
 pY1150/1151IRβ 1.193, 0.177 (0.225, 0.433) 1.070, 0.068 (0.247, 0.784) 1.074, 0.071 (0.256, 0.781) 1.562, 0.446 (0.297, 0.133) 0.979, − 0.0.1 (0.243, 0.930)
 pY960IRβ 1.604, 0.473 (0.229, 0.039) 1.319, 0.277 (0.244, 0.256) 1.518, 0.417 (0.259, 0.108) 1.667, 0.511 (0.286, 0.074) 1.397, 0.334 (0.245, 0.173)
  1. Separate age and sex adjusted ordinal logistic regression models, for each categorical infarct outcome measure (see text for methods, including description of 3 level outcome for outcome of “any infarct”, and 2 level outcome for other infarct outcomes); results which reach statistical significance are in bold (see methods for corrections for multiple comparisons)