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Table 1 Demographic information for CSF cases and results of αSyn RT-QuIC assay

From: Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies

 

PD

DLB

NS Controls

Total

Normal

ALS

MS

AD

Picks

CBD

PSP

No

88

58

68

23

9

6

7

10

4

9

Age, years (SD)

78.3 (8.1)

77.2 (8.8)

74.3 (10.9)

79.6(8.3)

72.2 (9.6)

66.3 (9.0)

70.9 (16.7)

68.5 (10.7)

74.5 (4.2)

79.1 (10.1)

Male, no. (%)

58 (66)

37 (64)

36 (53)

14 (61)

3 (33)

0 (0)

3 (43)

10 (100)

3 (75)

3 (33)

RT-QuIC assay

          

 ThT at 60 h, % (SE)

54.5 (2.2)

64.0 (2.5)

5.2 (0.2)

5.8 (0.4)

5.5 (0.4)

5.5 (0.4)

3.8 (0.4)

4.3 (0.5)

4.4 (0.8)

6.2 (1.6)

 P value (compared to PD)a

NA

< 0.05

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

 < 0.0001

0.0003

 P value (compared to NS total controls)a

 < 0.0001

 < 0.0001

NA

 > 0.99

 > 0.99

 > 0.99

 > 0.99

 > 0.99

 > 0.99

 > 0.99

  1. NA, not applicable
  2. a P values determined by one way analysis of variance with Tukey’s post hoc test