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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Fig. 4

Abundant neuronal inclusions in the inferior olivary nucleus in MSA patients. a Low and b higher magnification images of inferior olivary nucleus region stained with 5H12 antibody showing abundant αSyn inclusion pathology in the cell bodies and nucleus surrounded by extensive neuritic pathology. c Double labeling with anti-NFL (red) and anti-αSyn 5H12 (brown) antibodies in the inferior olivary nucleus region. d Perikaryal inclusions within the inferior olivary nucleus are also labeled by anti-ubiquitin staining. e IHC with anti-p62 antibody 5G3 in the inferior olivary nucleus. In a, b, d and e, the tissue sections were also counterstained with hematoxylin. Scale bar = 500 μm in A; 100 μm in be. Arrows depict neuronal inclusions within the inferior olivary nucleus and asterisks highlight GCIs

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