Fig. 8

Western blots of endolysosomal proteins in the zQ175 and R6/2 hippocampus. a Representative western blots of total protein hippocampal lysates from 6-month-old zQ175 mice and their wild-type littermates immunoprobed for LAMP1, RAB7, RAB27, CD63 or Cathepsin B (Cath-B). ATP5B served as loading control. b Quantification of the blot shown in a. c Western blots of total protein hippocampal lysates from 8-week-old R6/2 mice and their wild-type littermates immunoprobed for the same proteins as in a. d Quantification of the blot shown in c. e Western blotting of total protein hippocampal lysates from 12-week-old R6/2 mice and their wild-type littermates immunoprobed for the same proteins as in a. f Quantification of the blot shown in e. Statistical analysis was by Student’s t-test. n = 10 / genotype / age. The uncropped blots are shown in Additional File 1: Fig. S6-S8. Data represented by mean ± S.D. *p < 0.05; **p < 0.01; ***p < 0.001. Cath-B = Cathepsin B, WT = wild-type