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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Fig. 6

Ultrastructural analysis in zQ175 and R6/2 mice. a–h Representative recruitment foci in 6-month-old zQ175 and 12-week-old R6/2 mice. i Quantification of the number of MVB and autolysosome/residual bodies in zQ175 and R6/2 sections. j Quantification of the ratio between the number of recruitment foci with intraluminal lamellar structures and the total recruitment foci. k Quantification of the number of recruitment foci with phagophore-like double membrane structures as a ratio of the total number of recruitment foci. Four independent experiments with a total of 71 and 106 foci examined on TEM images for zQ175 and R6/2, respectively. Statistical analysis was two-way ANOVA, data represented by mean ± S.D. ***p < 0.001. l, m Serially displayed sections of two tomograms from c and d, presented as sequences taken as every 10th slice through the 8 × binned reconstructed tomograms. Related tomograms are shown in Additional File 4: Video S3 and Additional File 5: Video S4. Scale bars: 200 nm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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