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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Fig. 2

Co-localization of HTT-exon1-43Q signal with S830 antibody immunostaining. a HTT-exon1-43Q (green) was applied to TrueBlack treated zQ175 and wild-type brain sections from 6-month-old mice which were immunoprobed with the S830 antibody (magenta) and nuclei were counterstained with Hoechst (blue). HTT-exon1-43Q was recruited to perinuclear inclusions in the striatum, cortex, and hippocampus (CA1). b R6/2 and wild-type brain sections from 12-week-old mice treated with the HTT-exon1-43Q protein were immunoprobed with S830 and nuclei were counterstained with Hoechst. HTT-exon1-43Q was recruited to perinuclear inclusions as shown in the hippocampal CA1 region. c Enlarged areas from white boxed regions in a and b, respectively. The intensity profiles were plotted along the white dotted lines. The HTT-exon-43Q protein was not recruited to nuclear inclusions. Scale bars: 10 μm. WT = wild-type

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