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Table 2 Subjects with AD, PD, DLB, ILBD and with a normal neuropathological examination exhibited α-synuclein deposits in pancreatic β cells

From: Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein

Groups

Pα-synuclein

Cleaved α-synuclein

Nitrated α-synuclein

Subjects with a normal neuropathological examination

5/27 (19%)*

13/27 (48%)

4/27 (15%)

Subjects with a normal neuropathological examination and T2DM

6/13 (68%)*

18/19 (95%)

7/19 (37%)

AD with low neuropathologic change

11/28 (39%)

23/28 (82%)

7/28 (25%)

AD with intermediate neuropathologic change

13/26 (50%)

25/26 (96%)

15/26 (58%)

AD with high neuropathologic change

6/8 (75%)

8/8 (100)

4/8(50%)

Incidental Lewy body disease

5/8 (63%)*

8/8 (100%)

3/8 (38%)

Parkinson's disease

9/10 (90%)*

10/10 (100%)

6/10 (60%)

Dementia with Lewy bodies

11/12 (91%)*

12/12 (100%)

6/12 (50%)

  1. The data are represented as n (%). AD, Alzheimer disease; PD, Parkinson’s disease; DLB, dementia with Lewy bodies; ILBD, incidental Lewy body disease; T2DM, type two diabetes mellitus. *These results had been previously published in Martinez-Valbuena, et al. 2018 and have been added in this table to facilitate comparisons between groups
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Acta Neuropathologica Communications

ISSN: 2051-5960

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