Fig. 5From: Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion proteinIn situ proximity ligation assays (PLA) on pancreatic β cells and the locus coeruleus. PLA for PrP and α-synuclein (a–aʺ), serine 129-phosphorylated α-synuclein (c–cʺ), tau (e–eʺ), oligomeric tau (g–gʺ), Aβ (i–iʺ), Aβ1-42 (k–kʺ) or amylin (m–mʺ) with insulin immunofluorescence showed an interaction between these proteins in pancreatic β cells from a 73-year-old female with Parkinson’s disease (aʺ, cʺ) and from a 70-year-old male with Alzheimer’s disease (eʺ, gʺ, iʺ, kʺ, mʺ). Interactions between PrP and α-synuclein (bʹ, dʹ), tau (fʹ, hʹ), Aβ (jʹ, lʹ) or amylin (nʹ) were found in the locus coeruleus of the same subjects: DAPI nuclear counterstaining was used, 40 × magnification; scale bar = 50 µmBack to article page