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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein

Fig. 5

In situ proximity ligation assays (PLA) on pancreatic β cells and the locus coeruleus. PLA for PrP and α-synuclein (aaʺ), serine 129-phosphorylated α-synuclein (ccʺ), tau (eeʺ), oligomeric tau (ggʺ), Aβ (iiʺ), Aβ1-42 (kkʺ) or amylin (mmʺ) with insulin immunofluorescence showed an interaction between these proteins in pancreatic β cells from a 73-year-old female with Parkinson’s disease (aʺ, cʺ) and from a 70-year-old male with Alzheimer’s disease (eʺ, gʺ, iʺ, kʺ, mʺ). Interactions between PrP and α-synuclein (bʹ, dʹ), tau (fʹ, hʹ), Aβ (jʹ, lʹ) or amylin (nʹ) were found in the locus coeruleus of the same subjects: DAPI nuclear counterstaining was used, 40 × magnification; scale bar = 50 µm

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