Fig. 2

α-synuclein deposition in pancreatic β cells of subjects with Alzheimer’s disease. Immunohistochemistry for serine 129-phosphorylated α-synuclein immunofluorescence (a) C-terminal cleaved α-synuclein (b) and nitrated α-synuclein (c) from a 70-year-old female with Alzheimer’s disease. α-synuclein PLA (d), with insulin immunofluorescence (e) and DAPI as nuclear counterstaining (f) from a 73-year-old female with Alzheimer’s disease. Serine 129-phosphorylated α-synuclein immunofluorescence (g) and thioflavin S fluorescence (h) in pancreatic β cells from a 77-year-old female with Alzheimer’s disease (i): 40 × magnification; scale bar = 50 µm